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Short-chain fatty acids (SCFAs) consumed in the diet promote the expansion of Tregs in the gut, indicating the multifaceted role of SCFAs in regulating T cell differentiation

Valproate itself has multiple actions including modifying GABA levels by inhibiting 4-aminobutyrate aminotransferase (ABAT, GABA transaminase) and aldehyde dehydrogenase five family member A1 (ALDH5A1) which degrades GABA, thereby increasing inhibitory GABA availability

Patients often report feeling energised sooner