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Nanotechnology-Based drug delivery strategies to repair the mitochondrial function in neuroinflammatory and neurodegenerative diseases

Sabatino A, Regolisti G, Brusasco I, Cabassi A, Morabito S, Fiaccadori E

Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

Third, potential compensatory changes in other mitochondrial carriers following SLC25A39 knockout should be considered, future studies exploring chronic adaptations in carrier networks will be valuable

doi: 10.3390/diagnostics9040124 43 VyasJMuirheadNSinghREphgraveRFinlayAY

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