This drug has been shown to cause liver toxicity, and one of the mechanisms causing damage is the depletion of glutathione stores in the liver
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Also, CARN may have enhanced MTX distribution into cells, reducing its serum levels
Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
Capsaicin administered orally (12 mg/kg) or via enema (100 g) reduced DAI and histopathological damage, and improve the general symptoms in the colon of rats with DSS-induced colitis [206, 207]
Thus, aside from ferroptosis, some specific lipid peroxidation products have been demonstrated that contributes to the progression of various types of RCD (e.g., necroptosis, pyroptosis, apoptosis) [912]