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Mitochondrial superoxide anion can react with nitric oxide (NO) generating the reactive radical peroxynitrite (ONOO - ) and both superoxide anion and ONOO - formation in mitochondria are important events contributing to APAP-induced hepatotoxicity (Ramachandran and Jaeschke, 2017)

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Retrieved from Qian, L., Wang, W., Zhou, Y., & Ma, J

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Nrf2 knockout mice also exhibit lower GSH levels and are more susceptible to acetaminophen-induced liver injury [115]