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Life stress, the kindling hypothesis, and the recurrence of depression: considerations from a life stress perspective

Healthy fats round out the trio

Keep vitamin C supplementation down to 1-2 grams daily or use 10mg of B6 per gram of vitamin C if you choose to supplement higher

The interpretation of these transcriptomic findings has been a continuing area of discussion, with some researchers viewing the broad effects as evidence of a regulatory function and others viewing them with caution given the difficulty of distinguishing direct effects from secondary consequences in such broad gene-expression landscapes

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Neuropsychopharmacology 45 , 451461 (2020)