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The leading explanation is amplification of a pain-signaling channel on skin sensory nerves (purinergic ATP/P2X signaling). Symptoms were usually mild and eased after dose reduction

In clinical trials, the results are modest but real

Acute kidney injury from severe dehydration can be found through creatinine tests, often before any lasting damage happens

Some are looking for more energy, some want support with weight loss, and others need to restore low B12 levels or fill nutritional gaps from a plant-based diet

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Full disclosure I've also become more active and have been trying to maintain 10000 steps a day in addition to the GLP1 pills