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Together, these findings highlight the possible region-and sex-specific nature of KP dysregulation in MDD

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Furthermore, the EAE mouse with selective microglial C1q deletion or treated with C1q inhibitor showed reduced levels of microgliosis and signature markers of DAM and MIMS, although without improvement of the clinical score or change in the disease onset date

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Clinical studies have demonstrated that topical niacinamide improves the appearance of aging facial skin, including reductions in fine lines, wrinkles, yellowing, red blotchiness, and hyperpigmented spots, while also enhancing barrier function

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