10.1007/s13258-020-00987-9 [DOI] [PubMed] [Google Scholar] 41.Miao YL, Shi LH, Lei ZL, Huang JC, Yang JW, Ouyang YC, Sun QY, Chen DY
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The role of efflux and influx transporters, which are located on the brush border and/or basal membrane side of the syncytiotrophoblast, is additionally of fundamental importance [57,82]
With aging, multiple mechanisms contribute to mitochondrial dysfunction, including the accumulation of mitochondrial DNA (mtDNA) mutations, instability of respiratory chain complexes, imbalance in mitochondrial quality control, dysregulation of nutrient-sensing, and calcium overload [38, 83, 84]
nevertheless, it may have a strong genetic component as demonstrated by the evidence that it occurs more often in certain families compared with the general population (Ckaa and Strosznajder 2010)
Preclinical studies have shown it may protect the gastric mucosa from damage caused by NSAIDs, alcohol, and other mucosal irritants