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Multiple studies have shown that it was possible to decrease the expression of the UBE3A NAT, rescue the sense UBE3A expression, and ameliorate cognitive and behavioral phenotypes in a mouse model of AS through the RNAse-mediated degradation [59, 110]

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The method, use, or composition according to any one of claims 23-27, wherein the subject has a baseline intracellular level of GSH, tGSH, or both, of about 100-150 nM/10 5 WBC

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however, renal toxicity can also be manifested by changes in cell polarity, membrane integrity, and mitochondrial function

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