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It is reported that IGF-1 promotes hepatocyte proliferation, differentiation, cell cycle progression, and prolonging survival 30,31,32 , suggested that IGF-1 might repress cell premature aging and repair intrahepatic cells to ameliorate liver diseases

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2004;287(4):E591-601

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Herein, we review evidence supporting the actions of local IGF-I/IGF-IR in the above aspects of skeletal development and remodeling

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Both of these compounds are produced in small amounts in our body and obtained from multiple dietary sources

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