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A recent finding indicated that acute iron overload induces mtROS and depolarization of m, leading to mPTP opening and promoting calcium waves and arrhythmias, thereby positioning mPTP as a target for mitigating the arrhythmic effects of iron overload [89]

Phase 2 trials produced an average of 24.2% body weight reduction at the 12mg dose over 48 weeks

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Treatment of digoxin toxicity includes supportive correction of electrolyte imbalance

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[3] Nevertheless, they are part of the ATP-grasp superfamily, which consists of 21 enzymes that contain an ATP-grasp fold