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Experimental compounds like retatrutide should be reserved for formal clinical trials

In large randomized controlled trials, patients receiving semaglutide 2.4 mg lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, Wissam Ghusn, MD, postdoctoral research fellow from the division of gastroenterology and hepatology of the Precision Medicine for Obesity Laboratory at Mayo Clinic in Rochester, Minnesota, and colleagues wrote

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New York: Springer Science & Business Media (2012)

Some people also find that their tolerance for spicy or rich foods changes