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Mounjaro can cause light-headedness through several mechanisms: lowering blood glucose (especially with concurrent insulin or sulphonylureas), reducing fluid intake due to gastrointestinal side effects leading to dehydration, and causing orthostatic hypotension as blood pressure falls with weight loss

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However, during long-term or high-dose VPA therapy, or after acute VPA overdose, a greater degree of -oxidation occurs, potentially increasing the risk for toxicity

A multi-cohort meta-analysis reported an odds ratio of 1.60 for this variant, suggesting that it may impair renal or intestinal urate excretion, thereby increasing both hyperuricemia risk and susceptibility to tophus formation (184, 185)

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Liraglutide treatment also increased endothelial nitric oxide synthase (eNOS) and reduced intercellular adhesion molecule-1 (ICAM-1) expression in the aortic endothelium of atherogenic mice models ApoE / mice model [60]