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Doxil /Caelyx ), which is approved for the treatment of Kaposis sarcoma and recurrent ovarian cancer and is under clinical investigation for other malignancies, including breast cancer and glioblastomas [107]

Notably, the glutathione S-transferase proteins represent an extended family of multifunctional enzymes that are involved in diverse pathways such as oxidative stress response, and detoxification of various substrates 28

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