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As necrosis progresses, the tissues beneath your skin die

10.1016/j.nbd.2013.03.008 Neurobiol

However, experts note there is no scientific evidence to support this claim

First, while not much is known about plant mPGES-2s, mammalian mPGES-2s exhibit a dual subcellular localization associated to both the Golgi membrane through their N-terminal part and the cytoplasm after proteolytic cleavage of the N-terminal hydrophobic domain (Tanikawa et al., 2002

J Neuropathol Exp Neurol 2002