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The STEP 3 trial combined Wegovy with intensive behavioural support, including structured exercise guidance, and produced 16% average weight loss, reflecting how much lifestyle structure compounds the drug's effect

Hot flashes, mood stability, energy levels, and sleep quality often improve more dramatically than with either treatment alone, though formal studies specifically examining this combination remain limited

Patient Selection Semaglutide is recommended for adults with type 2 diabetes who have not achieved glycemic control with lifestyle changes or other medications

Early progress is a reliable predictor of ultimate outcome

This can further protect against heart disease and other cardiovascular conditions

Most patients take Rybelsus by mouth once per day