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Holman RR, Bethel MA, Mentz RJ et al (2017) Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

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demonstrated gene expression of several T2Rs in both the stomach and duodenum of mice and rats using reverse transcriptase-PCR ( 2+ indicated that a functional BTR-sensing system may be present on the enteroendocrine cells (1) (44)

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Key facts: Most GLP1s require refrigerated storage (check the product label for exact ranges and roomtemperature allowances) Thermal excursions even brief can degrade the active ingredients A documented, endtoend chain of custody supports quality, safety, and compliance Compliance Requirements Shipping GLP-1s GLP-1s are classified as temperature-sensitive biologic drugs, therefore pharmacies and distributors must follow regulatory agency guidelines like the FDA and other Good Distribution Practices (GDP)