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Lyophilised vials are stable at 20C for long-term storage

10.1016/S0140-6736(21)01324-6 83 RosenstockJ.FriasJ.JastreboffA

Some patients may experience mild side effects, such as nausea, fatigue, or digestive changes, especially when starting treatment

113 Three meta-analyses covering 11, 12 and 13 RCTs, respectively, all found a beneficial effect of NAC in reducing the number of exacerbations by 1025%

As PPA is metabolized through the TCAC, we propose that excess exogenous PPA or related short-chain fatty-acid metabolites interfere with mitochondrial metabolism, thereby causing acquired mitochondrial dysfunction