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Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

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Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Firdaus et al., 2018) by phosphorylating protein kinase B (Akt), Ser9 Glycogen synthase kinase-3 (GSK-3), and Fyn

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Mechanical stimuli, like shear stress, tensile stress, compressive loading, have been implemented, showing their influence on cell culture (99, 100)

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De Zeeuw CI, Hansel C, Bian F, Koekkoek SK, van Alphen AM, Linden DJ et al (1998)

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It can resemble a melanotic macule, showing melanin accumulation in the basal cell layer, or it may result from the deposition of drug-related metabolites as fine brown-yellow granules within the lamina propria [11,12]

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10.2147/OPTH.S25291 Kim J, Aschard H, Kang JH, et al.: Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank

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