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Elevated MOTS-c levels in senescent cells, which are exposed to these peptides, increased mitochondrial respiration and some senescence-associated secretory phenotypes (SASP) in the former, suggesting that mitochondria-secreted peptides exert a therapeutic effect by targeting mitochondrial energy and SASP production in senescent cells 50

Most available studies are underpowered, short-term, and heterogeneous in design, making it difficult to draw firm conclusions about long-term efficacy, optimal dosing strategies, or the specific patient subgroups most likely to benefit

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