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It was originally developed by Novo Nordisk and has been the subject of multiple Phase I and Phase II clinical trials, making it one of the better-characterised GHS peptides in terms of safety and pharmacokinetic data

185 Inconsistencies in the outcome of these studies might be attributed to the heterogeneity of the populations studied and/or different conditions of analysis and concentrations of plasma cysteine used

The initiator of the pathophysiological process has not been elucidated yet, although acute gastrointestinal infections have been found to initiate the symptoms in a certain group of patients with IBS (post-infectious IBS) (81)

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Journal of Horticulture and Postharvest Research 4:95106