Beyond lipid metabolism, the GLP-1 RAs also shown critical anti-inflammatory and antioxidant effects, collectively positioning these GLP-1 RAs as a leading pharmacotherapy for MASLD (Pasta et al., 2025
A structured summary of key RCTs, including intervention details, effect sizes, and methodological limitations, is provided in Table 5
reported in their study that ellagic acid evaded MDR more efficiently than 3,4-Dihydroisocoumarins in drug-resistant cancer cell lines such as HCT-15 (that increases the expression of P-gp), and MCF-7/MX (that raises the expression of BCRP), respectively, at much lower doses than the iso-coumarin derivative [215]
These include improvements in blood glucose control, reductions in blood pressure, and better overall metabolic function
In cases of vitamin D deficiency, NGF levels may decrease, which may negatively impact neuroplasticity
In addition to therapies derived from treatment of clonal MC disorders, novel approaches warrant further study
