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10.1038/nature22800 36 JoS.KimT.IyerV

At baseline, mean age was 47 years (range 18 to 80), 74% were female, 86% were White, 4% were Asian and 9% were Black or African American

Thus, the transient nature of estrogen elevations in female rats may limit estrogens facilitatory effects on GLP-1 signaling, potentially explaining the more robust disruption of alcohol discrimination observed in males