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ZEPBOUND **General Notes:**- All listed drugs are administered as once-weekly subcutaneous injections.- Off-label use for weight loss has been common for Ozempic and Mounjaro prior to the approval of Wegovy and Zepbound for obesity.- Dosages vary by patient needs and indication but typically start at lower doses and are titrated up.- Main risks under emerging research include potential severe vision complications (e.g., NAION) in addition to commonly known side effects

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Exenatide is available as a BID or once-weekly (OW) formulation where the latter comprises exenatide encapsulated in microspheres of poly (d,l lactic-co-glycolic acid) for gradual drug delivery 15

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Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S et al (2019) Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial