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This is critical, because malignant melanoma may present with a deceptively benign clinical appearance

Proc Natl Acad Sci U S A (2012) 109:797481.10.1073/pnas.1120210109 28 FryeREMelnykSMacfabeDF

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Obesity is an enduring public health issue in its own right and the weight loss industry is booming even without the health aspect, meaning demand for the drugs is often beyond supply

It wasn't the long half-life and the potency that eventually got us to where we are today