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In the case of discontinuous supplementation of creatine, such as disruption for short intervals (e.g., 1 or 2 days per week), a longer period of supplementation (e.g., by 510 days) should still be sufficient to achieve the saturation of creatine in skeletal muscle

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Neurosci Med

This version is generally very well tolerated and helpful

Sleep fragmentation induces AQP4 mislocalization from astrocytic endfeet, reducing CSF clearance efficiency

It is difficult to draw conclusions based on human clinical experience due to a number of variables