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tied to MC1R activity

Cell-based therapies, particularly those that leverage the capacity of stem cells for decidualization or epithelial differentiation, offer a potential solution to improve endometrial function

Second, structural biology: cryo-EM structures of full-length MC4R in complex with heterotrimeric Gs, published in Cell Research in 2021, resolved bremelanotide in the orthosteric site alongside alpha-MSH, afamelanotide and a small-molecule agonist, establishing a conserved binding mode for the peptidic ligands and a distinct activation mechanism for MC4R

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