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The DONEPEZOX trial, as a proof-of-concept, randomized, triple-blind, and multicenter study, will be the first clinical trial to evaluate the efficacy and safety of donepezil in oxaliplatin for gastrointestinal cancer-induced severe peripheral neuropathy (OIPN), with the response rate in the donepezil group (neuropathy grade reduction according to the QLQ-CIPN20 sensory score) as the primary endpoint [168]
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