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doi: 10.1038/ng.2901 47

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Clinical and translational studies have reported substantial changes in body weight and adipose tissue mass when the compound is evaluated in controlled trials and metabolic models, suggesting that multi-receptor agonism can alter energy balance through integrated endocrine signaling mechanisms [2][3][5]

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Technically you can charge without the balancing plug attached, but honestly - you should not, it can easily lead to a fire since one cell might get over discharged since only the total voltage is being monitored but not the individual ones