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Larger, randomized trials are underway

The protein-protein interaction network of first episode psychosis and schizophrenia reveals possible trigger factors and new drug targets among intracellular signal transduction pathways and neurotoxicity processes

However, evidence supporting its efficacy is limited, and it may lead to an undesirable increase in blood pressure

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* [ 20-22] Alpha-glycerophosphocholine (Alpha-GPC), CDP-Choline (or Citicoline), and Uridine Monophosphate support the goals of augmenting choline pools and providing full pathway support