It acts as the ultimate electron donor for the glutaredoxin system, which activates ribonucleotide reductase (RNR) , the rate-limiting enzyme responsible for converting ribonucleotides into the deoxyribonucleotides (dNTPs) needed for DNA replication
Gonzalez, M
Rosen, R., Diamond, L., Earle, D., Shadiack, A., & Molinoff, P
Malabsorption can cause severe B12 deficiency
DIA files were processed using Spectronaut with default settings, with PTM localization activated and site confidence score cutoff set to 0 (for peptide-level analysis of dilution benchmark), 0.75 (for spectral library analysis) or 0.99 (for direct DIA analysis), data filtering set to Q- value and Normalization Strategy set to Local Normalization