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Possible Mechanisms Behind the Conflicting Results The mixed results on GLP-1 receptor agonists and mental health could be due to several things

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Functional complementation of the H 2 O 2 -sensitive yeast growth by transforming GhGPXs in gpx3 mutant yeasts The GPX homolog YIR037W / HYR1 / GPX3 was found in the Saccharomyces Genome Database, and a previous study indicated that gpx3 mutant was hypersensitive to peroxides, and with decreased ~57% GPX activity in gpx3 mutants with respect to wild type (BY4741) 47

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Statistical analysis Each experiment was carried out in triplicate