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Moreover, Cotadutide was demonstrated to decrease fat accumulation in the liver and retard hepatic fibrogenesis developing in high-fat diet (HFD) and HFD/CCl4 mouse models (138, 139)

These changes lead to central sensitization, where non-painful stimuli are perceived as painful (allodynia), and pain responses are amplified (hyperalgesia)

This research peptide was initially studied as a tanning agent due to its affinity to melanocortin receptor 1 (MC1-R)

By enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, these drugs create a multifaceted approach to managing blood sugar levels and reducing appetite

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