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Cryotherapy risks primarily involve direct cold injury (frostbite) from excessive exposure duration or temperature

Studies in medial collateral ligament repair and segmental bone-defect models have reported earlier restoration of structural integrity, better-organised collagen architecture and accelerated callus formation effects consistent with enhanced local vascularisation

Greibe E, Miller JW, Foutouhi SH, Green R, Nexo E (2013) Metformin increases liver accumulation of vitamin B12 - an experimental study in rats

Tan X, Liu Q, Fang Y, Yang S, Chen F, Wang J, et al

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