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Citation: Bhatt DL et al

For Bargiela, one aspect stood out above all others output

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Section 503A, in turn, allows for patient-specific compounding performed by (1) a licensed pharmacist in a state-licensed pharmacy or federal facility, or (2) a licensed physician for example, for patients who are allergic to certain inactive ingredients, need a liquid formulation rather than a pill, or need a lower strength than what is commercially available The Rise and Fall of GLP-1 Compounding As we detailed here, compounding pharmacies entered the GLP-1 market in 2022 when demand for semaglutide and tirzepatide outstripped supply and both drugs hit the FDA Drug Shortage List, resulting in the emergence of a multibillion-dollar sub-industry

The 10mg vial suits researchers running the Phase 2 low-dose 1mg cohort (10 weeks of weekly dosing from a single vial), the early-escalation weeks of any higher cohort (the 2mg initiation period across the 4mg/8mg/12mg cohorts uses 8mg total over 4 weeks), or pilot research where a minimal commitment is preferred before scaling to the 20mg or 30mg formats