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Gregory, F

Patients should contact their healthcare provider if they experience severe or persistent side effects, signs of hypoglycaemia (particularly if taking insulin or sulfonylureas), symptoms of pancreatitis (severe abdominal pain), or if there is no improvement in blood glucose control after 6 months of treatment at the maximum tolerated dose

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This concept is supported by the reduced ability (by 90) of IGF-I / osteoblasts to induce osteoclastogenesis of spleen cells cultured from WT mice (65)

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