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This dual mechanism (direct and secondary) likely contributes to the overall motility dysfunction observed with GLP-1 RA therapy, which can result in bowel obstruction, particularly in individuals with preexisting motility issues

[PubMed] [Google Scholar] 153.Slenter I.J.M., Djajadiningrat-Laanen S.C., Elders D.J., de Gee R., Koele L.E., Vermeer L.W., Boev M.H

Conversely, Glp1r mRNA expression is highest in the jejunum within the epithelial fraction, followed by ileum then colon (Kedees et al., 2013)

Treating the entire skin at once would lead to a very long recovery with high risk for infection and complication (think intense chemical peels and fully ablative laser therapy)

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