This specific high-ROS environment triggers the hyperproliferation of memory T-cellsthe immune system gets stuck in an overdrive loop, replicating cells unnecessarily and draining massive amounts of energy
Importantly, consider the broader clinical picture
Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis
TRAIL induces podocyte PANoptosis via death receptor 5 in diabetic kidney disease
[DOI] [PubMed] [Google Scholar] 184.Wang X.Y., Qu M., Duan R., Shi D., Jin L., Gao J., Wood J.D., Li J., Wang G.D
This also requires careful experiment planning to minimize vial openings