Because their reconstitution solvent maintains sterility and preservative capacity throughout the protocol timeline, not just at the beginning
Researchers should avoid placing the vial in the coldest part of the refrigerator, such as directly against the back wall, where temperatures can fluctuate or dip low enough to affect solution stability
[PubMed] Storage and Handling (Laboratory Use Only) Store lyophilized material at -20C or below, protected from light
For those with hematologic or renal risks, repeat testing at reasonable intervals (for example, after a few doses and then periodically) makes sense
Proper storage slows this process dramatically, but it does not stop it
When comparing the different routes, the top-ranked route for increasing levels of vitamin B12 was the IM route, followed by the SL route