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The SURMOUNT-4 Trial The Most Important Study The SURMOUNT-4 randomized clinical trial is the most comprehensive study examining what happens when patients stop tirzepatide

Rushing produces more discomfort, more missed doses due to side effects, and paradoxically slower progress

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GLP-1, or glucagon-like peptide-1, enhances insulin secretion, inhibits glucagon release, and slows gastric emptying, leading to reduced appetite and increased satiety

Choose low-glycemic carbohydrates (sweet potatoes, steel-cut oats, quinoa, most vegetables) over high-glycemic options (white rice, white bread, potatoes) to minimize blood sugar spikes