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Third, drug delivery represents difficulties, especially for targeting deep vascular tissues penetration or achieving VSMC-specific localization without affecting endothelial or immune cells

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Typically, injections will be less expensive than IV drip therapy

The intestinal microbiota exerts also a crucial role in the maturation of the innate immune system, since gut bacteria are a driving force in this process

Moreover, HSV-1-induced ferroptosis played an important role in the development of viral encephalitis in mice, and the upregulation of PTGS2 and PGE 2 activated by ferroptosis contributes to encephalitis (Fig