At 48 weeks, 93% of participants on the 12 mg dose achieved normal liver fat levels (below 5%), with a mean relative reduction of 86% in hepatic fat content
The scientists looked at the health records of more than 95,000 patients, including 22,480 people who used GLP-1s
The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration
Nakao A
Clinical data shows that most people regain approximately two-thirds of lost weight within 12 months of stopping GLP-1 therapy
Lastly, ongoing research into the molecular pathways involved in DN will be crucial for identifying new therapeutic targets