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This result was explained by the authors as the lack of hepatocellular ballooning in a more consistent percentage of subjects within the pioglitazone group on initial biopsies as assessed after central review

Antioxid Redox Signal 8:404416 Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM (2005) Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor NRF2