PMID 2555512
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
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TABLE 4 Time to onset analysis of dehydration after treatment with three GLP-1RAs
"The classic framework is that if you only have one, it comes down from the list price to 75 per cent," Tadrous said
Only two of the clinical trials analyzed in the study provided weight data, which showed no difference in weight loss between those with and without PAM variants, but the data is too limited to be conclusive, Gloyn said