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1 Bartelt, K., Joyce, B., Trinkl, J., & Deckert, J

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With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source

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Mechanical Overload Excess body weight significantly increases the mechanical load placed on weight-bearing joints

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