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The binding of HGF to c-met was detected with biotinylated anti-HGF polyclonal Ab (1:500 dilution in the 0.1% BSA-TTBS for 3 h at 25C), TACS streptavidin-HRP conjugate (1:1600 dilution for 20 min), and TMB substrate solution

Moreover, compared to using metformin or simvastatin alone, the combination of both drugs had a significant impact (Fig

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Step 2: Add the recyclers

In a murine model of AD, melatonin diminished GSK3 activity [61], an effect potentially reliant on melatonin receptor MT1, as implied by findings in SH-SY5Y cells [62]

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