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Kumrungsee T et al

Consequently, promising interventions often fail to demonstrate meaningful clinical impact, revealing the limitations of current models and endpoint [566]

Abnormal activation of pathways or obstruction of autophagic flux may lead to functional imbalance

these drugs may have improved efficacy and reduced adverse effect profiles, providing much needed therapeutic choice before considering irreversible sub-total pancreatectomy as a last resort for the treatment of severe and recurrent hypoglycaemia

doi: 10.1073/pnas.1017213108 126 Ushio-FukaiMAlexanderRW

The availability of cysteine appears to be the rate limiting factor for synthesis of GSH