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The functional significance of ERK1/2 activation by BPC-157 is further supported by inhibitor studies: when the ERK pathway is pharmacologically blocked, BPC-157s pro-migratory and pro-angiogenic effects are abolished, underscoring the pathways critical role in mediating cellular activity [55]

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Radeljak S, Seiwerth S, Sikiric P

For high-risk patients or those with documented decline despite optimal lifestyle measures, referral to clinical trials of emerging anabolic/anti-catabolic therapies is appropriate