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Upon hypoxia, HIF-1 is stabilized and translocates to the nucleus, where it dimerizes with HIF-1, binds to target genes, and activates gene transcription

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doi:10.1038/cdd.2010.80 Ruzza P, Rosato A, Rossi CR, Floreani M, Quintieri L (2009) Glutathione transferases as targets for cancer therapy

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These components can be further oxidized to form CoA derivatives that can enter the citric acid cycle and CO 2 , respectively

5,61 As an example, orally administered GSH ethyl ester is able to significantly raise GSH concentrations in the liver, kidney, spleen, pancreas, heart, and lung of the mouse, and in human red blood cells, skin fibroblasts, and several lymphoid cell lines