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The disease is characterized by: *Chronic lymphocytic infiltration of the thyroid gland *Elevated TPO antibodies (TPOAb) - present in over 90% of cases *Elevated thyroglobulin antibodies (TgAb) - present in 5080% of cases *Progressive thyroid fibrosis and loss of function *Eventual hypothyroidism requiring lifelong levothyroxine replacement The Oxidative Stress Signature of Hashimoto's The Antioxidants review (2021) confirmed that patients with Hashimoto's thyroiditis show a consistent pattern of oxidative stress markers: elevated malondialdehyde (MDA - a lipid peroxidation marker), reduced superoxide dismutase (SOD) activity, and critically, significantly decreased glutathione levels compared to healthy controls

doi: 10.3389/fphar.2022.901234 172 ZhangXHuWWuYSunKZhouYLLuFet al

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Cholangiofibrosis (Figures 123126) Synonyms Bile duct adenomatosis

Puerarin ameliorates depressive symptoms in diabetic mice induced by high-fat diet